(alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic Acid 4-ethyl Ester Calcium Salt

(alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt

CAS No.:1369773-39-6

[Synonyms]

(2S,4R)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2-methylpentanoic acid ethyl ester,calcium salt(2:1)

(alphaR,gammaS)-gamma-[(3-Carboxy-1-oxopropyl)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoic acid 4-ethyl ester calcium salt (2:1)

AHU-377 hemicalcium salt (2:1)

Calciumbis(4-{[(1S,3R)-1-([1,1'-biphenyl]-4-ylmethyl)-4-ethoxy-3-methyl-4-oxobutyl] amino} -4-oxobutanoate);

[Melting point] >140°C (dec.)

[Density] 1.24g/cm3 at 20°C

[Vapor pressure] 0.001Pa at 20°C

[Storage temp.] -20°C

[Solubility] DMSO (Slightly, Heated), Methanol (Slightly)

[Form] powder

[Color] white to beige

[Logp] -0.66-2.9 at 20°C and ph2-7

[FDA UNII] 8F45HCQ47Q

[Uses]

Sacubitril is an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

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