Description
This product is a clear liquid, colorless or almost colorless, slightly viscous.
Pharmacological Action
Pharmacodynamics：Paracetamol (acetaminophen) has antipyretic and analgesic effects. Its antipyretic effect is similar to that of aspirin, but its analgesic effect is weaker. It has a strong inhibitory effect on prostaglandin synthesis and release in the hypothalamus, but a weaker effect on peripheral prostaglandin synthesis and release. It has no effect on platelets or the coagulation mechanism. It is mainly used as an antipyretic and analgesic in small and medium‑sized animals for fever, muscle pain, joint pain, and rheumatism.
Pharmacokinetics：It is mainly metabolised in the liver, with most of the drug being conjugated with glucuronic acid or sulfate and excreted by the kidneys. In the liver, a portion of the drug is deacetylated to form p‑aminophenol, which is then oxidised to iminoquinone. Iminoquinone can oxidise haemoglobin in the body, causing loss of oxygen‑carrying capacity, which may lead to tissue hypoxia, cyanosis, haemolysis of red blood cells, jaundice, and liver damage, among other adverse reactions.
Action and Use
Antipyretic and analgesic agent. Used for fever, muscle pain, joint pain, and rheumatism.
Dosage and Administration
Intramuscular injection: single dose - horses, cattle 50–100 ml; sheep 5–20 ml; pigs 5–10 ml; dogs 1–5 ml.
Adverse Reactions
Occasionally causes anorexia, vomiting, hypoxia, cyanosis, haemolysis of red blood cells, jaundice, and liver damage.
Precautions
(1) Contraindicated in cats, as severe toxic reactions may occur after administration.
(2) High doses may cause liver and kidney damage. Administration of acetylcysteine or methionine within 12 hours after dosing can prevent liver damage. Use with caution in animals with hepatic or renal insufficiency and in young animals.
Withdrawal Period
No withdrawal period required.
Specification
(1) 5 ml : 0.5 g
(2) 10 ml : 1 g
(3) 20 ml : 2 g
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