Albendazole and Avermectin Tablets

What is Albendazole and Avermectin Tablets?

Antiparasitic agent. Albendazole exhibits broad-spectrum anthelmintic activity and demonstrates strong efficacy against nematodes, cestodes, and trematodes. Its mechanism of action involves binding to tubulin in helminths, thereby disrupting cellular processes such as mitosis, protein assembly, and energy metabolism within the parasites.

Avermectin is highly effective against both internal and external parasites, particularly arthropods and nematodes. It is primarily used to control gastrointestinal nematodes, lungworms, and external parasites in animals such as cattle and sheep. Its anthelmintic action is mediated by stimulating the release of gamma-aminobutyric acid (GABA) from presynaptic neurons, which opens GABA-gated chloride channels. The influx of chloride ions reduces membrane resistance, causing a slight hyperpolarization of the postsynaptic membrane potential and disrupting neuromuscular signal transmission. This leads to paralysis and subsequent death or expulsion of the parasites.

What is the Physicochemical Properties of Albendazole and Avermectin Tablets?

This product is a white or off-white tablet.

Uses

What is Albendazole and Avermectin Tablets used for?

Antiparasitic agent. Used for the treatment of nematodiasis, trematodiasis, cestodiasis, and acariasis in cattle and sheep.

Dosage

How much Albendazole and Avermectin Tablets should be given to an animal?

Oral administration: Single dose: 1 tablet per 10kg body weight for cattle and sheep.

Side Effects

What are the potential side effects of Albendazole and Avermectin Tablets in different animal species?

No adverse reactions have been observed when used at the recommended dosage and administration.

What are the common dosage forms of Albendazole and Avermectin Tablets?

0.153g (Avermectin 3mg + Albendazole 0.15g).

What are the Precautions of Albendazole and Avermectin Tablets?

(1) Contraindicated during the lactation period.

(2) Avermectin is slightly more toxic than ivermectin; use with caution in sensitive animals.

(3) Avermectin is sensitive to light and can be rapidly inactivated by oxidation; it should be stored protected from light.

(4) This product is highly toxic to fish and shrimp. Do not allow residues, packaging materials, or animal excreta to contaminate water sources.

(5) Withdrawal period: Cattle and sheep: 35 days.

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