Decoquinate is a quinoline compound traditionally used in veterinary medicine for the prevention and treatment of livestock as an antibiotic. It is administered in combination with other antimicrobial agents in the production of food animals.
The primary veterinary use of Decoquinate is attributed to its physicochemical properties, particularly its lipophilicity, which limits its solubility in aqueous fluids and inhibits its absorption in the gastrointestinal tract.
This compound possesses antiparasitic, anticoccidial, and antihistomoniasis (blackhead disease) effects, making it suitable as a poultry feed additive to prevent and control coccidiosis caused by the protozoan Eimeria. Parasites of this genus can infect a wide range of animals, including cattle, sheep, goats, and horses, all of which can be treated with Decoquinate.
1.Product Nature
CAS No.: 18507-89-6
Molecular Formula: C₂₄H₃₅NO₅
Molecular Weight: 417.54
Appearance: Solid
Color: White to off-white
2.Origin and Mechanism of Action
Decoquinate was developed by May & Baker Ltd (UK) in the 1960s. It exhibits broad-spectrum anticoccidial activity and is effective against coccidiosis caused by Eimeria species, including E. tenella, E. maxima, E. acervulina, and E. brunetti.
Decoquinate acts by interfering with the DNA synthesis of coccidia, thereby inhibiting their replication. It features low toxicity, good tolerance, and rapid absorption, enabling it to reach effective concentrations quickly. Additionally, it is rapidly metabolized in animals, resulting in low residue levels. Due to these advantages, Decoquinate has been widely adopted in Europe, the United States, and other regions.
3.Mechanism of Action of Quinoline Anticoccidials:
Quinoline-class anticoccidial agents exert their effect by disrupting electron transport within the cytochrome system of coccidial mitochondria, thereby inhibiting mitochondrial respiration. Studies have confirmed that their target site is cytochrome b.
Cytochrome b is a critical component of the cytochrome bc1 complex (ubiquinol-cytochrome c reductase), located in the inner mitochondrial membrane. It serves as a central element of the mitochondrial electron transport chain, essential for energy production in the parasite.
*Corresponding Common Veterinary Dosage Forms
Decoquinate Solution(100ml:3g)
*FAQ and Knowledge
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