Product Overview
Technical briefing and clinical profile of Decoquinate feed-grade micro-granule premix.
Decoquinate 6% Premix (chemically identified as ethyl 6-(decyloxy)-7-ethoxy-4-hydroxyquinoline-3-carboxylate, CAS: 18507-89-6) is a specialized synthetic 4-hydroxyquinoline anticoccidial feed additive manufactured by Well Sunshine Group. Formulated as a free-flowing, dustless micro-granule containing 60 g of active decoquinate per kilogram, it delivers powerful chemoprophylactic protection against avian coccidiosis caused by all six major pathogenic Eimeria strains in commercial broilers (Eimeria tenella, E. necatrix, E. acervulina, E. maxima, E. brunetti, and E. mitis), as well as clinical coccidiosis in young ruminants (calves and lambs).
The distinctive pharmacological hallmark of Decoquinate is its exceptionally early Day-1 site of action in the parasite life cycle. By selectively disrupting electron transport across the cytochrome bc1 complex of the mitochondrial respiratory chain, Decoquinate arrests newly excysted sporozoites within the intestinal lumen before they can penetrate host enterocytes. Because parasite cellular invasion is blocked at inception, intestinal mucosal architecture remains completely intact with zero lesion scores, safeguarding nutrient absorption and optimizing feed conversion efficiency throughout critical growth phases.
Key Pharmacological Advantages & Commercial Values
Why feed manufacturers and poultry integrators incorporate Decoquinate 6% Premix into intensive production programs.
Day-1 Sporozoite Blockade
Acts immediately on Day 1 post-ingestion upon excystation, destroying sporozoites before they can penetrate gut epithelial cells and trigger tissue damage.
Zero Intestinal Lesions
Pre-invasion arrest eliminates mucosal bleeding, sloughing, and subclinical lesion scores, preserving optimum gut barrier integrity and superior feed conversion ratio (FCR).
1.8 μm Micro-Granule Tech
Engineered via specialized micronization into ~1.8 μm micro-particles, overcoming water insolubility to guarantee uniform gastrointestinal distribution and mixing homogeneity.
Local Action & Broad Margin
Virtually unabsorbed into the bloodstream, acting locally within the intestinal lumen. Low tissue residue profile provides a manageable 5-day chicken withdrawal period.
Mode of Action (MOA) & Mitochondrial Dynamics
Four-stage biological sequence of Decoquinate antiparasitic activity in vivo.
Gastrointestinal Release
Micro-granules break down rapidly within the digestive tract, dispersing fine particles across the digesta to coat the mucosal surface.
Cytochrome bc1 Binding
Decoquinate selectively binds to the mitochondrial cytochrome bc1 complex (Complex III) of free, excysted Eimeria sporozoites.
ATP Respiration Block
Inhibits mitochondrial cellular respiration and halts ATP generation, paralyzing sporozoite motility before enterocyte penetration.
Mucosal Preservation
Halts the lifecycle at Day 1, entirely aborting 1st and 2nd generation schizogony and eliminating clinical hemorrhage and oocyst shedding.
Certified Quality Specifications (COA Standard)
Analytical verification standards compared against certified representative production batch results.
| Test Parameter | Quality Standard (Reference: CPV 2020) | Representative Batch Result | Compliance Status |
|---|---|---|---|
| Description & Appearance | Alike white to yellow free-flowing granule | Alike white to yellow granule | Complies |
| Identification | Positive chemical reaction | Positive reaction confirmed | Complies |
| Assay of Decoquinate | 90.0% – 110.0% of labeled amount (5.40% – 6.60%) | 101.0% (6.06% w/w Active Decoquinate) | Complies |
| Loss on Drying | ≤ 10.0% | 4.2% | Complies |
| Filling Level / Uniformity | Should comply with enterprise standard | Conforms to standard specifications | Complies |
| Conclusion | Complies with the Enterprise Standard established reference to CPV 2020 | Complies | |
Recommended Species Dosages & Mixing Protocols
Strict inclusion guidelines per Metric Ton of complete feed for target animal categories.
Commercial Meat Broilers
453 g / Metric Ton FeedDelivers 27.2 ppm active Decoquinate. Administer continuously in complete feed for 7–14 consecutive days or throughout starter/grower rearing periods.
Young Calves & Lambs
0.5 mg / kg Body WeightAdminister via starter ration or milk replacer daily for 28 consecutive days to prevent coccidial enteritis caused by Eimeria bovis and E. zuernii.
Stepwise Industrial Pre-Dilution
1 : 10 Pre-Blend RatioPre-mix 453 g Decoquinate 6% Premix thoroughly with 10–20 kg feed carrier (fine corn flour) before discharging into the main batch mixer to ensure CV ≤ 5%.
Clinical Precautions, Regulatory Warnings & Storage
Essential operational guidelines for safe and effective feed mill inclusion.
- STRICT BENTONITE CONTRAINDICATION: Decoquinate must never be used in feeds containing bentonite or montmorillonite clay binders. The expansive smectite clay lattice adsorbs the decoquinate molecule, rendering it biologically unavailable and neutralizing anticoccidial efficacy.
- Continuous Administration Mandate: Because Decoquinate prevents sporozoite penetration, the host immune system is not exposed to second-generation antigens and cannot develop natural immunity. In broilers, medication must be continuous throughout the entire high-risk rearing window.
- Resistance Management Protocols: Due to potential single-gene mutation resistance under protracted single-drug use, Decoquinate should be systematically rotated with chemical coccidiostats or ionophores.
- Withdrawal Period & Storage: Chickens: 5 days. Store in tightly closed original packaging in a cool, dark, dry warehouse (≤ 25°C). Shelf life: 24 months.
Compatibility & Synergistic Feed Programs
Strategic biosecurity and rotation architectures combining Well Sunshine specialized veterinary additives.
Shuttle Program with Dinitolmide
Use Decoquinate 6% Premix in the broiler starter phase (0–21 days) for lesion-free early gut growth, shuttling to Dinitolmide 25% Premix in the grower phase to stimulate flock active immunity.
Rotation with Diclazuril & Nicarbazine
Rotate seasonally with Diclazuril 0.5% Premix or Nicarbazine 25% Premix to break chemical tolerance cycles in intensive commercial complexes.
Necrotic Enteritis Control with Enramycin
Combine with Enramycin 8% Premix. Decoquinate protects epithelial barrier integrity, while Enramycin eliminates Clostridium perfringens, delivering comprehensive enteric security.
Frequently Asked Questions (FAQ)
Technical answers to common commercial formulation and biosecurity inquiries.
Q1: Why is Decoquinate strictly prohibited in feed rations containing bentonite?
Bentonite clays (montmorillonite) possess high adsorption capacities and active interlamellar cations that electrostatically bind decoquinate micro-granules in the digestive chyme. This adsorption prevents decoquinate from interacting with excysted sporozoites, reducing bioactivity by 50% to 80% and resulting in coccidiosis outbreaks.
Q2: How does Day-1 sporozoite arrest preserve gut health compared to other anticoccidials?
Most anticoccidials act on Day 3 or Day 4 after parasites have already penetrated intestinal villi and caused hemorrhage. Decoquinate paralyzes sporozoites on Day 1 before epithelial invasion occurs. Consequently, gut epithelial cells remain intact with zero lesion scores and unimpaired nutrient absorption.
Q3: Why must Decoquinate be fed continuously throughout the broiler rearing period?
Because Decoquinate halts sporozoite development before significant antigenic presentation occurs, birds do not synthesize natural protective immunity against Eimeria. Premature withdrawal exposes naive birds to environmental oocysts; therefore, unbroken continuous feeding until the 5-day pre-slaughter withdrawal is required.
Q4: What is the tissue residue and withdrawal profile for Decoquinate 6% Premix?
Decoquinate is virtually insoluble in water and exhibits negligible systemic absorption through the gut wall, acting locally. Tissue residues in edible muscle clear rapidly, requiring an official withdrawal period of only 5 days in chickens before slaughter for human consumption.
Procure Certified Decoquinate 6% Premix Directly from Well Sunshine
Direct factory supply with complete COA batch release, global shipping documentation, and customized formulation support for poultry and livestock feed manufacturers worldwide.
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Decoquinate 6% Premix
CAS NO.: 18507-89-6
Specifications: 6% Premix.
Characteristics: Yellow granule or Off white powder.
Indications:
Coccidiostat, for the prevention of poultry coccidiosis. It has a great effect on E.tenella, Eimeria Acervulina, E.nacatrix, Eimeria Brunetti, E.maxima.
Pharmacology:
Decoquinate 6% Premix plays a role in the asexual reproduction stage of the coccidia, after enter the coccidia spore cells, by interfering with DNA synthesis and preventing its development. It begins to play a role in the early coccidia life cycle, thus avoiding damage to the poultry intestine.
Usage&Dosage:
Mixed Feeding. Recommended Dosage:
|
Animal Species |
Decoquinate 6% Premix |
Decoquinate Concentration |
|
Chicken |
453 |
27.18 |
Precautions:
- It cannot be used in feeds containing bentonite.
- Quinoline coccidiostat are easy to produce drug resistance. It is suggested that this product is only used in the coccidia outbreak peak use. And continuous use is no more than 4 weeks.
Withdrawal Period: 5 days.
Package: 25 kg/bag
Storage: Store in a cool and dry place, in sealed or closed container.
Expiry: Two years.
You Can Trust Well Sunshine Group: 20 Years in Coccidiosis Control
Well Sunshine Group has specialized in the production of Anticoccidial Feed Additives for two decades. With a comprehensive portfolio of dozens of specialized varieties and scientifically-proven Rotation Programs, we don't just supply products-we provide holistic solutions to manage resistance and optimize flock health.
