Product Overview
Technical description and chemical profile of Diclazuril 0.5% Premix for commercial poultry and rabbit production.
Diclazuril 0.5% Premix (chemically designated as (2-(3,4-dichlorophenyl)-2-(4-chlorophenyl)-2-(3,5-dichloro-4-oxo-4,5-dihydro-1,2,4-triazin-3-yl)acetonitrile), CAS: 101831-37-2) is a specialized synthetic triazine coccidiocide manufactured in strict accordance with the Chinese Veterinary Pharmacopoeia (CPV 2020). Formulated to deliver 5,000 mg of active Diclazuril per kilogram (0.5% w/w), the product utilizes an electrostatic-neutral, highly fluid yellow micro-granule carrier that guarantees dust-free processing and micro-dispersion in compound mash and pelleted feeds.
Unlike traditional ionophore feed additives that merely suppress coccidial proliferation, Diclazuril functions as a decisive, broad-spectrum cidal agent. Its primary pharmacodynamic activity peaks against invasive sporozoites and first-generation schizonts during the first 48 hours (Days 1–2) of the Eimeria lifecycle. In addition, it blocks second-generation schizogony, gametocyte maturation, and oocyst wall formation, halting mucosal lesions and shedding. Featuring an inclusion rate of only 200 g per metric ton (1 ppm active Diclazuril), minimal tissue accumulation (<0.063 mg/kg after 7 days), and a fast 48-hour metabolic clearance, Diclazuril 0.5% Premix delivers dependable prevention across commercial broilers, waterfowl, and rabbits with a 5-day chicken and 14-day rabbit withdrawal interval.
Key Pharmacological Advantages
Formulated for commercial feed mills and poultry integrators, providing decisive coccidiocide prevention against pathogenic Eimeria with superior blending uniformity.
Broad-Spectrum Cidal Power
Exerts true cidal destruction across all economically devastating avian Eimeria strains (E. tenella, E. acervulina, E. necatrix, E. brunetti, E. maxima) and rabbit species (E. stiedae, E. magna).
Early Day 1–2 Parasite Arrest
Attacks invaded sporozoites and first-generation schizonts during the first 48 hours of infection, arresting parasitic multiplication before intestinal mucosal lesions can form.
Complete Oocyst Cycle Interruption
Disrupts gametogony and prevents oocyst wall cross-linking, eliminating fecal oocyst excretion and breaking the reinfection cycle in commercial poultry houses.
Minimal Tissue Residue & Safety
Negligible systemic gastrointestinal absorption; active fraction stays in gut lumen. Average tissue residue 7 days post-withdrawal is below 0.063 mg/kg, ensuring high consumer food safety.
Mode of Action & Biological Dynamics
Targeted cellular inhibition pathway of synthetic Diclazuril across asexual and sexual coccidial development stages.
Sporozoite Infiltration Blockade
Within 0–24 hours post-ingestion, active Diclazuril penetrates host enterocytes to arrest sporozoite metabolic respiration and organelle differentiation.
Schizont Lysis & Arrest
At 24–48 hours, it destroys first-generation schizonts before merozoite release, preventing enterocyte rupture, cecal hemorrhage, and bloody diarrhea.
Gametocyte Suppression
Suppresses microgametocyte flagellation and inhibits wall-forming body synthesis, completely halting oocyst sporulation and environmental shedding.
Rapid Clearance & Zero Buildup
Fast metabolic clearance with no tissue accumulation; anticoccidial action dissipates within 48 hours post-withdrawal, requiring continuous in-feed supply.
Guaranteed Technical Specifications
Certified chemical specifications conforming to Chinese Veterinary Pharmacopoeia (CPV 2020) standards.
| Item of Test | CPV 2020 Standard Requirement | Typical Batch Result (Batch 20230126) |
|---|---|---|
| Appearance / Description | Yellow Granule, uniform free-flowing micro-granules | Conforms (Yellow Granule) |
| Identification (Chemical) | Positive chemical reaction | Conforms (Positive) |
| Identification (HPLC) | Same retention time as reference standard peak | Conforms (HPLC Verified) |
| Loss on Drying | ≤ 10.0% | 1.2% |
| Active Assay (Diclazuril, HPLC) | 0.45% – 0.55% (4.5 – 5.5 g/kg) | 0.512% (5.12 g/kg) |
| Standard Compliance | Chinese Veterinary Pharmacopoeia CPV 2020 | Conforms in full to CPV 2020 requirements |
Recommended Inclusion Rates & Administration Guide
Practical dosage guidelines across commercial broiler, replacement pullet, waterfowl, and rabbit production.
Broiler Chickens & Replacement Pullets
Mix 200 g of Diclazuril 0.5% Premix per 1,000 kg of complete feed. Administer continuously throughout the coccidiosis challenge period (e.g. starter and grower phases) to safeguard mucosal integrity and maintain optimum FCR.
Ducks, Geese & Commercial Waterfowl
Incorporate 200 g per 1,000 kg of complete mash or pelleted feed. Provides broad-spectrum protection against duck Eimeria, Tyzzeria perniciosa, and goose renal coccidiosis with high safety tolerance.
Commercial Meat & Breeding Rabbits
Add 200 g per 1,000 kg of complete rabbit feed from weaning onward. Highly effective against both hepatic coccidiosis (Eimeria stiedae) and intestinal coccidiosis (E. magna, E. media, E. perforans).
Critical Step-Wise Pre-Dilution & Operational Instructions
- Mandatory 3-Stage Pre-Dilution: Due to the low inclusion concentration (200 g per 1,000 kg feed, a 1:5,000 ratio), progressive pre-mixing is strictly required to achieve a coefficient of variation (CV) < 5%: First blend 200 g of premix with 2–5 kg of cereal flour/carrier; secondly mix into 20–50 kg of feed ingredients; finally blend into the primary batch mixer.
- Continuous Administration Required: Diclazuril has a short metabolic half-life. Drug efficacy declines sharply within 24 hours of feed withdrawal and disappears after 48 hours. Feeding must be uninterrupted during risk windows.
- Laying Hen Contraindication: Do not administer to laying hens during the laying period producing eggs for human consumption.
- Withdrawal Period: Broiler chickens: 5 days; Rabbits: 14 days before slaughter.
- Storage Conditions: Store in tightly sealed original packaging, protected from light, in a dry, ventilated warehouse. Shelf life: 24 months.
Compatibility & Synergistic Feed Programs
Strategic rotation schemes, shuttle programs, and synergistic feed additive combinations to maximize gut health and suppress resistance.
Clopidol 25% Premix
Integrate with Clopidol 25% Premix in annual chemical rotation programs. Alternating Diclazuril's cidal schizont destruction with Clopidol's Day-1 sporozoite arrest eliminates cross-resistance development in broiler operations.
Nicarbazine & Robenidine
Deploy Nicarbazine 25% Premix in starter feeds during cool brooding phases, followed by Diclazuril or Robenidine Hydrochloride 10% Premix in grower diets for uninterrupted enteric security.
Enramycin 8% & BMD Premix
Combine with Enramycin 8% Premix or Bacitracin Methylene Disalicylate (BMD) to target Clostridium perfringens, stopping secondary necrotic enteritis triggered by subclinical coccidiosis.
Vitamin E & Coated Cysteamine
Enhance flock recovery with Vitamin E 50% Powder and Allicin Powder to restore gut villi, paired with Coated Cysteamine HCL 50% to boost digestive enzymes and maximize ADG.
Frequently Asked Questions (FAQ)
Key technical and operational questions regarding Diclazuril 0.5% Premix application in animal nutrition.
1. How does Diclazuril differ from ionophore anticoccidials?
Unlike polyether ionophores (such as monensin or salinomycin) which interfere with cation transport across cell membranes and primarily act as coccidiostats, Diclazuril is a synthetic triazine derivative that exerts true cidal action across multiple lifecycle stages. It carries zero cross-resistance to ionophores, has no negative impact on feed palatability or feathering, and remains safe in hot summer climates without risk of ionophore-associated heat exhaustion or cardiac stress.
2. Why is continuous feeding essential with Diclazuril 0.5% Premix?
Diclazuril undergoes rapid gastrointestinal transit and metabolic elimination. Pharmacokinetic trials demonstrate that its protective anticoccidial concentration in intestinal contents decreases significantly within 24 hours of removal and practically disappears within 48 hours. Interrupting feed administration during high-challenge periods leaves the flock unprotected and may allow dormant or newly ingested oocysts to cause a rapid disease outbreak.
3. What is the withdrawal period and can it be used in laying hens?
The official withdrawal period is 5 days for chickens and 14 days for rabbits prior to slaughter for human consumption. Diclazuril is strictly contraindicated in laying hens during their egg-laying period if eggs are intended for human consumption, to eliminate the risk of trace residues in commercial table eggs.
4. Why is progressive step-wise pre-mixing mandatory in commercial feed mills?
Because the recommended inclusion rate is 200 g per metric ton of complete feed (1:5,000 ratio), direct addition of such a small quantity into a large batch mixer can result in uneven distribution, localized under-dosing, or micro-hotspots. A 3-stage progressive dilution (pre-mixing with carrier, then expanding into a sub-batch before final addition) ensures homogeneous dispersion with a coefficient of variation (CV) < 5%.
Global Supply & Technical Consultation
Well Sunshine Group supplies high-potency, CPV 2020-compliant Diclazuril 0.5% Premix to feed mills, premix blenders, and commercial poultry integrators worldwide. Contact our veterinary technical team for customized shuttle programs, bulk quotations, and technical dossiers.
No. 318, Baishi Lane, Hangzhou, China
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Diclazuril
CAS NO.: 101831-37-2
Specifications: 0.5% Premix.
Characteristics:
Pure: Light yellow or fawn-colored, feckly odorless.
Indications:
As a kind of new-type, high-efficiency and low-toxicity anti-coccidiosis drug, it is widely used for chicken coccidiosis disease. It can reach the peak effect on coccidiosis. It has reliable destroying and inhibiting effect to all kinds of coccidia.
Pharmacology:
Inhibit the proliferation of spores and schizont.
Usage&Dosage:
Mixed feeding. Recommended Dosage:
|
Animal Species |
Diclazuril 0.5% Premix |
Diclazuril Concentration |
|
Chicken |
200 |
1 |
Advantages:
- High stability and safety.
- Low dosage owning to its high potency.
- Drug resistance won't happen.
- To increase the rate of weight gained of chicken.
Withdrawal Period: 7 days.
Package:
Pure：25 kg/drum.
Premix: 25 kg/bag.
Storage: Store in a cool and dry place, in sealed or closed container.
Expiry: Two years.
