WELBUTY90 (Coated Sodium Butyrate 90%)
Sodium Butyrate
[Physicochemical Properties and Metabolism of Sodium Butyrate]:
Sodium butyrate has the molecular formula CH₃CH₂CH₂COONa. It is a white, hygroscopic powder with a melting point of 250.0–253.0 °C and a distinct rancid cheese-like odor. As an organic salt of butyric acid, it is highly soluble in water and stable under light and heat. Butyric acid is a short-chain volatile fatty acid primarily produced by beneficial gut microbiota (e.g., Lactobacillus and Bifidobacterium) through the fermentation of carbohydrates and proteins in the large intestine. Butyrate can enter the liver via the portal vein and be converted to butyryl-CoA, which is further metabolized into ketone bodies, fatty acids, and cholesterol. The resulting ketone bodies can be synthesized into adenosine triphosphate (ATP), providing energy for intestinal mucosal cells. The unabsorbed portion enters other organs and tissues for metabolism.
[Mechanisms of Sodium Butyrate in Regulating Intestinal Health of Livestock and Poultry]:
(1) Sodium butyrate maintains the structural integrity of the intestinal mucosa, promoting robust and well-arranged villi, increasing the thickness of the intestinal muscle layer and mucosa, and improving the villus height-to-crypt depth ratio.
(2) It serves as a rapid energy source for intestinal epithelial cells.
(3) It supports intestinal development in livestock and poultry, enhances relative intestinal length, upregulates the relative expression of colonic EGF, and increases intestinal mucosal thickness.
(4) Sodium butyrate stimulates the secretion of immunoglobulins and other immune factors in the intestinal mucosa, enhancing intestinal immune function and reducing the occurrence of inflammation.
(5) It promotes the activity of digestive enzymes in the intestine.
(6) It lowers intestinal pH and improves the intestinal microecology.
[Concepts]:
Concept 1: Short-chain fatty acids (SCFAs) are organic fatty acids with carbon chains of 1–6, primarily consisting of acetate, propionate, and butyrate. The level of butyrate is a key indicator of intestinal health.
Concept 2: Undigested carbohydrates and fibrous polysaccharides that reach the large intestine are converted into SCFAs by anaerobic bacteria. Any factor affecting the substrates (undigested carbohydrates and fibrous polysaccharides) or the activity of anaerobic bacteria will directly reduce SCFA production.
Concept 3: SCFAs, particularly butyrate, are essential nutrients for the colonic mucosa. Butyrate oxidation accounts for 75% of the oxygen consumption in colonic epithelial cells.
[Active Ingredient]: Sodium Butyrate
[Content]: ≥90%
[Molecular Formula]: CH₃CH₂CH₂COONa
[Molecular Weight]: 110.09
Well Sunshine Group has been dedicated to the research and production of sodium butyrate products for over a decade. The company has developed coated products such as WELBUTY30 (Coated Sodium Butyrate 30%) and WELBUTY90 (Coated Sodium Butyrate 90%), and leads in the production capacity of 99% sodium butyrate powder. Well Sunshine Group's animal health products have been sold to nearly 100 countries and regions worldwide.
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