Description
This product is a clear liquid, colorless to pale yellow.
Pharmacological Action
This product is a broad‑spectrum antibacterial agent. It is the most potent sulfonamide both in vitro and in vivo, with strong inhibitory activity against most Gram‑positive and Gram‑negative bacteria. Bacteria develop resistance to this drug relatively slowly. It has good antibacterial activity against both Gram‑positive and Gram‑negative bacteria such as Streptococcus pyogenes, Salmonella spp., and Klebsiella pneumoniae. Sulfonamides are structurally similar to para‑aminobenzoic acid (PABA) and can compete with PABA for the bacterial enzyme dihydropteroate synthase, thereby inhibiting the synthesis of dihydrofolic acid, ultimately affecting nucleic acid synthesis and suppressing bacterial growth and reproduction. The action of sulfonamides can be antagonized by PABA and its derivatives (procaine, tetracaine). In addition, pus and tissue breakdown products can provide essential nutrients for bacterial growth, producing an antagonistic effect against sulfonamides.
Action and Use
Sulfonamide antibacterial agent. It is used for infections caused by susceptible bacteria, and also for Toxoplasma gondii infections in pigs, among others.
Dosage and Administration
Intravenous injection: single dose, per 1 kg body weight, domestic animals 0.5 ml. Administer once or twice daily for 2–3 consecutive days.
Adverse Reactions
(1) Sulfonamides or their metabolites may precipitate in the urine, especially at high doses or during prolonged low‑dose administration, leading to crystalluria, hematuria, or blockage of renal tubules.
(2) Intravenous injection in horses may cause transient paralysis.
(3) Sulfonamide injection solutions are strongly alkaline and highly irritating to tissues.
Precautions
(1) This product may precipitate when mixed with acids, therefore it should not be diluted with 5% glucose solution.
(2) Long‑term or high‑dose administration may easily cause crystalluria; sodium bicarbonate should be administered concurrently, and the animal should be provided with plenty of water.
(3) If allergic reactions or other serious adverse effects occur, discontinue administration immediately and provide symptomatic treatment.
Withdrawal Period
Withdrawal period: domestic animals 28 days; milk discard period 7 days.
Specification
(1) 5 ml : 0.5 g
(2) 10 ml : 1 g
(3) 20 ml : 2 g
(4) 50 ml : 5 g
(5) 100 ml : 10 g
Hot Tags: sulfamonomethoxine sodium injection, manufacturers, suppliers, factory, wholesale, custom
