What is Levamisole Hydrochloride Tablets?
Pharmacodynamics: This product belongs to the imidazothiazole class of anthelmintics and is active against most nematodes in cattle, sheep, pigs, dogs, and chickens. Its anthelmintic mechanism involves stimulating both parasympathetic and sympathetic ganglia of the parasite, exhibiting a nicotinic-like action; at high concentrations, it interferes with nematode carbohydrate metabolism by blocking fumarate reduction and succinate oxidation, ultimately leading to paralysis and expulsion of the live parasites.
In addition to its anthelmintic activity, this product significantly enhances immune responses. It restores cell-mediated immune function in peripheral T lymphocytes, stimulates phagocytosis by monocytes, and exerts more pronounced effects in immunocompromised animals.
Pharmacokinetics: This product is absorbed from the gastrointestinal tract after oral administration, distributes throughout the body upon absorption, and is largely metabolized in the liver and kidneys. Metabolites are primarily excreted in urine, with less than 6% excreted unchanged; a small amount is excreted in feces. Plasma half-lives are approximately: 4–6 hours in cattle, 3–4 hours in sheep, 3.5–6.8 hours in pigs, and 1.8–4 hours in dogs.
What is the Physicochemical Properties of Levamisole Hydrochloride Tablets?
This product is a white tablet.
Uses
What is Levamisole Hydrochloride Tablets used for?
Imidazothiazole anthelmintic agent. Primarily used for gastrointestinal nematodes, lungworms, and swine kidney worm disease in cattle, sheep, pigs, dogs, cats, and poultry.
Dosage
How much Levamisole Hydrochloride Tablets should be given to an animal?
Oral administration: Single dose: 1.5 tablets per 10kg body weight for cattle, sheep, and pigs; 2 tablets for dogs and cats; 5 tablets for poultry.
Side Effects
What are the potential side effects of Levamisole Hydrochloride Tablets in different animal species?
(1) In cattle, parasympathetic excitation symptoms such as frothing at the mouth/nose, salivation, excitation or tremors, lip licking, and head shaking may occur. Symptoms generally subside within 2 hours.
(2) In sheep, temporary excitation may occur after administration; goats may exhibit depression, hyperesthesia, and salivation.
(3) In pigs, salivation or frothing at the snout may be observed.
(4) In dogs, gastrointestinal disturbances (e.g., vomiting, diarrhea), neurotoxic reactions (e.g., panting, head shaking, anxiety, or other behavioral changes), agranulocytosis, pulmonary edema, and immune-mediated skin rashes have been reported.
(5) In cats, salivation, excitation, mydriasis, and vomiting may occur.
What are the common dosage forms of Levamisole Hydrochloride Tablets?
50mg.
What are the Precautions of Levamisole Hydrochloride Tablets?
(1) Not for use in laying poultry producing eggs for human consumption; not for use in livestock producing milk for human consumption during the lactation period.
(2) Use with caution or postpone use in severely debilitated animals, animals with significant hepatic or renal impairment, or in cattle under stress from procedures such as vaccination, dehorning, or castration.
(3) Atropine can be used as an antidote for poisoning, along with other symptomatic treatments.
(4) Withdrawal period: Cattle: 2 days; Sheep: 3 days; Pigs: 3 days; Poultry: 28 days.
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