What is Sulfadimidine Tablets?
Pharmacodynamics: This product demonstrates good antibacterial activity against both Gram-positive and Gram-negative bacteria, such as Streptococcus pyogenes, Salmonella, and Klebsiella pneumoniae. Sulfonamides structurally resemble *p*-aminobenzoic acid (PABA) and compete with it for bacterial dihydrofolate synthase, thereby inhibiting the synthesis of dihydrofolic acid. This ultimately disrupts nucleic acid synthesis and suppresses bacterial growth and reproduction. The action of sulfonamides can be antagonized by PABA and its derivatives (e.g., procaine, tetracaine). Additionally, pus and tissue breakdown products can supply essential materials for bacterial growth, further antagonizing sulfonamide efficacy. The antibacterial activity of this product is slightly weaker than that of sulfadiazine, but it exhibits strong inhibitory effects against coccidia and Toxoplasma.
Pharmacokinetics: The pharmacokinetic profile of this product is generally similar to that of sulfadiazine. However, it has a higher plasma protein binding rate, resulting in slower excretion. It is rapidly and completely absorbed after oral administration but excreted slowly, maintaining effective blood concentrations for an extended period. Due to the high solubility of its acetylated metabolites, it has a lower incidence of crystalluria in renal tubules and is less likely to cause crystalluria or hematuria. The elimination half-life is 10.7–12.9 hours in cattle and horses, 15.3 hours in pigs, and 4.7–5.8 hours in dairy goats and buffalo.
What is the Physicochemical Properties of Sulfadimidine Tablets?
This product is a white to slightly yellow tablet.
Uses
What is Sulfadimidine Tablets used for?
Sulfonamide antibacterial agent. Used for infections caused by susceptible bacteria, as well as for coccidial and Toxoplasma infections.
Dosage
How much Sulfadimidine Tablets should be given to an animal?
Oral administration: Single dose: For livestock, initial dose of 28–40 tablets per 100kg body weight, maintenance dose of 14–20 tablets per 100kg body weight. Administer once or twice daily for 3–5 consecutive days.
Side Effects
What are the potential side effects of Sulfadimidine Tablets in different animal species?
Sulfonamide or its metabolites may precipitate in urine, with crystallization, crystalluria, hematuria, or renal tubular obstruction more likely to occur at high doses or with prolonged administration.
What are the common dosage forms of Sulfadimidine Tablets?
0.5g.
What are the Precautions of Sulfadimidine Tablets?
(1) May crystallize in the urinary tract. Ensure adequate water intake for treated animals. Administer with an equivalent amount of sodium bicarbonate when used at high doses or for prolonged periods.
(2) Use with caution in animals with impaired renal function due to reduced excretion.
(3) May disrupt intestinal flora. Prolonged use can reduce the synthesis and absorption of B vitamins and vitamin K; supplement accordingly.
(4) Discontinue immediately and provide symptomatic treatment if allergic reactions occur in livestock.
(5) Withdrawal period: Cattle: 10 days; Sheep: 28 days; Pigs: 15 days. Milk discard period: 7 days.
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