Description
This product is a colorless to slightly yellow clear liquid.
Pharmacological Action
This product exerts good antibacterial activity against both Gram-positive and Gram-negative bacteria.Sulfonamides are structurally similar to para-aminobenzoic acid (PABA) and can compete with PABA for dihydropteroate synthase in bacteria, thereby inhibiting dihydrofolate synthesis and ultimately affecting nucleic acid production to suppress bacterial growth and reproduction.The activity of sulfonamides may be antagonized by para-aminobenzoic acid and its derivatives (procaine, tetracaine). In addition, pus and tissue breakdown products may also provide essential nutrients for bacterial growth and antagonize sulfonamides.Trimethoprim is an antibacterial potentiator that inhibits dihydrofolate reductase activity. The combination of the two produces a synergistic effect and enhances antibacterial efficacy.
Action and Use
Sulfonamide antibacterial agent. For the treatment of infections of the urinary tract, respiratory tract, skin and soft tissues caused by susceptible bacteria.
Dosage and Administration
Dosage: 0.75–1 mL per 10 kg body weight in livestock. Frequency: Once or twice daily, for 2–3 consecutive days.
Adverse Reactions
Acute reactions include hypersensitivity/allergic reactions. Chronic reactions may present as granulocytopenia, thrombocytopenia, hepatic injury, renal injury and central nervous system toxicity.
Precautions
This product may precipitate crystals in acidic conditions; therefore, it should not be diluted with 5% glucose solution.
Long-term or high-dose administration may easily cause crystalluria. Sodium bicarbonate should be administered concurrently, and a large amount of drinking water should be provided to the animals.
If allergic reactions or other severe adverse reactions occur, discontinue use immediately and provide symptomatic treatment.
Trimethoprim and sulfonamides must not be used in dogs and horses with hepatic parenchymal damage.
Withdrawal Period
Withdrawal period: 28 days for livestock; 7 days for milk.
Specification
10 ml: Sulfamonomethoxine Sodium 2 g, Trimethoprim 0.4 g
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