What is Florfenicol Soluble Powder?
Pharmacodynamics: Florfenicol is a broad-spectrum amphenicol antibiotic with bacteriostatic activity. It acts by binding to the 50S ribosomal subunit, inhibiting bacterial protein synthesis. It exhibits strong antibacterial activity against a wide range of Gram-positive and Gram-negative bacteria. Pasteurella multocida, Mannheimia haemolytica, and Actinobacillus pleuropneumoniae are highly susceptible to florfenicol. In vitro, the antibacterial activity of florfenicol against many microorganisms is similar to or stronger than thiamphenicol. Some bacteria resistant to amphenicols due to acetylation, such as Escherichia coli and Klebsiella pneumoniae, may still be susceptible to florfenicol.
It is primarily used to treat bacterial diseases in pigs, chickens, and fish caused by susceptible bacteria, such as bovine and porcine respiratory diseases caused by Mannheimia haemolytica, Pasteurella multocida, and Actinobacillus pleuropneumoniae; typhoid and paratyphoid caused by Salmonella; fowl cholera, pullorum disease, colibacillosis, etc.; and bacterial septicemia, enteritis, red-skin disease, etc., in fish caused by Pasteurella, Vibrio, Staphylococcus aureus, Aeromonas hydrophila, Enterobacter spp., etc.
Pharmacokinetics: Florfenicol is rapidly absorbed after oral administration, reaching therapeutic concentrations in the blood within approximately 1 hour and peak plasma concentrations within 1–3 hours. Its bioavailability exceeds 80%. Florfenicol is widely distributed in animal tissues and can cross the blood-brain barrier. It is primarily excreted unchanged in urine, with a small amount eliminated in feces..
What is the Physicochemical Properties of Florfenicol Soluble Powder?
This product is a white or off-white powder..
Uses
What is Florfenicol Soluble Powder used for?
Amphenicol antibiotic. Used for the treatment of bacterial diseases in chickens caused by susceptible bacteria.
Dosage
How much Florfenicol Soluble Powder should be given to an animal?
For medicated drinking water: Chickens: 2–4g per liter of water, for 3–5 consecutive days.
Side Effects
What are the potential side effects of Florfenicol Soluble Powder in different animal species?
This product exhibits strong immunosuppressive effects when administered at doses higher than recommended.
What are the common dosage forms of Florfenicol Soluble Powder?
Premix: 5%.
What are the Precautions of Florfenicol Soluble Powder?
For poultry producing eggs for human consumption, this product must not be used during the egg-laying period.
(2) Use with caution in breeding chickens.
(3) Contraindicated during vaccination periods or in animals with severely compromised immune function.
(4) Withdrawal period for chickens: 5 days.
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