What is Robenidine Hydrochloride Tablets?
This product demonstrates high efficacy against Eimeria tenella, E. necatrix, E. brunetti, E. maxima, E. acervulina, and E. mitis in chickens, and remains effective against coccidia strains resistant to other anticoccidial agents. It primarily inhibits the development of first-generation schizonts, with additional activity against second-generation schizonts. Its peak activity occurs on day 3 post-infection. It is also effective against various Eimeria species in rabbits. The mechanism of action involves disruption of the endoplasmic reticulum in the parasite cytoplasm, interfering with protein metabolism and causing swelling of the endoplasmic reticulum and Golgi apparatus, while inhibiting oxidative phosphorylation and ATP production. Coccidia can readily develop resistance to this agent.
Following oral administration in chickens, the drug is metabolized into nine metabolites, including p-chlorotoluene. Within 24 hours after a single dose, 82% of the administered dose is excreted, reaching 99% excretion after 6 days.
What is the Physicochemical Properties of Robenidine Hydrochloride Tablets?
This product is a white or off-white tablet.
Uses
What is Robenidine Hydrochloride Tablets used for?
Anticoccidial agent. Used for coccidiosis.
Dosage
How much Robenidine Hydrochloride Tablets should be given to an animal?
Oral administration: Single dose: 1–1.5 tablets per kg body weight for chickens and rabbits.
Side Effects
What are the potential side effects of Robenidine Hydrochloride Tablets in different animal species?
No adverse reactions have been observed when used at the recommended dosage and administration.
What are the common dosage forms of Robenidine Hydrochloride Tablets?
10mg.
What are the Precautions of Robenidine Hydrochloride Tablets?
(1) Not for use in laying chickens producing eggs for human consumption.
(2) Discontinuation of treatment too early when used against certain coccidial species may lead to disease recurrence. Continuous administration is required.
(3) Withdrawal period: Chickens: 5 days; Rabbits: 7 days.
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