What is Chlorpromazine Hydrochloride Tablets?
Pharmacodynamics: Chlorpromazine is a central dopamine receptor blocker with multiple pharmacological activities. It potentiates the central inhibitory effects of drugs such as anesthetics, analgesics, and anticonvulsants. It also inhibits the hypothalamic thermoregulatory center, leading to a significant reduction in body temperature. Additionally, chlorpromazine blocks peripheral α-adrenergic receptors, directly dilates blood vessels, relieves spasm of small arteries and veins, improves microcirculation, and exhibits anti-shock effects.
Pharmacokinetics: This product is readily absorbed after oral administration but undergoes significant first-pass metabolism. In monogastric animals, the time to peak plasma concentration is approximately 3.0 hours. After absorption, about 95% of the drug binds to plasma proteins. Chlorpromazine is highly lipophilic, widely distributed throughout the body, readily crosses the blood-brain barrier (achieving higher concentrations in the brain than in plasma), and can cross the placental barrier into the fetus. It is primarily metabolized in the liver via hydroxylation and sulfoxidation, with some metabolites retaining pharmacological activity. Most metabolites are excreted in urine, a small portion in feces, and some undergo enterohepatic recirculation. The half-life in dogs is approximately 6.0 hours. This product is metabolized very slowly, and residues can persist in animals for several months.
What is the Physicochemical Properties of Chlorpromazine Hydrochloride Tablets?
This product is a white tablet.
Uses
What is Chlorpromazine Hydrochloride Tablets used for?
Sedative. Used for potentiation of anesthesia and to calm animals.
Dosage
How much Chlorpromazine Hydrochloride Tablets should be given to an animal?
Oral administration: Single dose: 0.8–1.2 tablets per 10kg body weight for dogs and cats.
Side Effects
What are the potential side effects of Chlorpromazine Hydrochloride Tablets in different animal species?
Excessive doses may cause adverse reactions in animals such as dogs and cats, including arrhythmia, tremors of the limbs and head, and even rigidity of the limbs and trunk.
What are the common dosage forms of Chlorpromazine Hydrochloride Tablets?
25mg.
What are the Precautions of Chlorpromazine Hydrochloride Tablets?
(1) For hypotension induced by overdose, epinephrine is contraindicated for reversal; norepinephrine may be used instead.
(2) Use with caution in animals with jaundice, hepatitis, nephritis, or in elderly and debilitated patients.
(3) Administration may alter most physiological parameters (e.g., respiration, heart rate, body temperature); this should be considered during clinical examination.
(4) No withdrawal period is required.
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