Description
This product is a clear liquid, colorless to slightly yellow.
Pharmacological Action
Thiamphenicol is an amphenicol antibiotic with broad‑spectrum antibacterial activity. It is more active against Gram‑negative bacteria than against Gram‑positive bacteria. It is highly active against most Enterobacteriaceae, including Salmonella typhi, Salmonella paratyphi, Escherichia coli, and Salmonella spp. Other sensitive Gram‑negative bacteria include Pasteurella spp., Brucella spp., etc. Sensitive Gram‑positive bacteria include Bacillus anthracis, Streptococcus spp., Corynebacterium spp., Streptococcus pneumoniae, Staphylococcus spp., etc. Chlamydia, Leptospira, and Rickettsia are also sensitive to this product. It also has considerable activity against anaerobes such as Clostridium tetani and Actinomyces spp. However, Mycobacterium tuberculosis, Pseudomonas aeruginosa, and fungi are not sensitive to it.
Pharmacokinetics：This product is rapidly and completely absorbed after oral administration. After absorption, it is widely distributed in various tissues. It is excreted mainly unchanged in the urine. The elimination half‑life in cattle and sheep is shorter than that of chloramphenicol; in pigs, the elimination half‑life is 4.2 hours.
Action and Use
Amphenicol antibiotic. Used for the treatment of infections caused by susceptible bacteria in the digestive and respiratory tracts of pigs, such as paratyphoid in piglets, white scour, pneumonia, and colibacillosis.
Dosage and Administration
Calculated as this product. Intramuscular injection: per 1 kg body weight, pigs 0.1 ml. Administer once or twice daily for 2–3 consecutive days.
Adverse Reactions
(1) This product has haematopoietic toxicity, mainly reversible inhibition of erythropoiesis, but aplastic anaemia has not been reported.
(2) This product has strong immunosuppressive effects.
Precautions
Contraindicated in animals during vaccination periods or with severely impaired immune function.
Withdrawal Period
Withdrawal period: 28 days.
Specification
(1) 5 ml : 0.25 g
(2) 10 ml : 0.5 g
(3) 10 ml : 1.0 g
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