Description
This product is a clear liquid, almost colorless to yellow.
Pharmacological Action
Pharmacodynamics：Ciprofloxacin lactate is a broad‑spectrum bactericidal agent exclusively for veterinary use. It acts by inhibiting bacterial DNA gyrase (GyrA subunit), thereby suppressing bacterial DNA replication and transcription, leading to bactericidal effects. It has good antibacterial activity against most Gram‑negative bacteria and cocci, including Pseudomonas aeruginosa, Klebsiella spp., Escherichia coli, Enterobacter spp., Campylobacter spp., Shigella spp., Salmonella spp., Aeromonas spp., Proteus spp., Haemophilus spp., Yersinia spp., Serratia spp., and Vibrio spp. Brucella spp., Chlamydia trachomatis, Staphylococcus spp. (including penicillinase‑producing and methicillin‑resistant strains), Mycoplasma spp., and Mycobacterium spp. are also sensitive. It has weak antibacterial activity against anaerobes and is ineffective against anaerobic infections.
This product is significantly more effective against Gram‑negative bacteria than other drugs in its class, and has the strongest in vitro antibacterial activity against Pseudomonas aeruginosa.
Pharmacokinetics：The plasma protein binding rate of ciprofloxacin varies significantly among animal species: 70% in cattle, 23% in pigs. It is excreted mainly unchanged in the urine. The elimination half‑life after intravenous injection is 4.9 hours in horses, 2.4 hours in calves, 1.3 hours in sheep, 1.5 hours in goats, 3.1 hours in pigs, 9.0 hours in chickens, and 2.6 hours in dogs.
Action and Use
Fluoroquinolone antibacterial agent. Used for bacterial and mycoplasma infections in livestock and poultry.
Dosage and Administration
Intramuscular injection: single dose, per 10 kg body weight - domestic animals 0.5 ml; poultry 1 ml. Administer twice daily.
Intravenous injection: single dose, per 10 kg body weight - domestic animals 0.4 ml. Administer twice daily.
Adverse Reactions
(1) Causes cartilage degeneration in young animals, affecting bone development and leading to lameness and pain.
(2) Digestive system reactions include vomiting, loss of appetite, and diarrhoea.
(3) Skin reactions include erythema, pruritus, urticaria, and photosensitivity reactions.
Precautions
(1) Use with caution in young breeding stock and foals intended for reproduction.
(2) Contraindicated in pregnant and lactating animals.
(3) Use with caution in carnivores and animals with renal insufficiency. In animals with severe renal or hepatic disease, the dose should be adjusted to avoid drug accumulation.
(4) Contraindicated in laying hens during the egg‑laying period.
Withdrawal Period
Withdrawal period: cattle 14 days, pigs 10 days, poultry 28 days; milk discard period 84 hours.
Specification
Calculated as ciprofloxacin:
(1) 5 ml : 0.25 g
(2) 10 ml : 0.5 g
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