What is Paracetamol Tablets?
Pharmacodynamics: Paracetamol exhibits antipyretic and analgesic effects. Its antipyretic action is similar to aspirin, but its analgesic effect is weaker. It strongly inhibits the synthesis and release of prostaglandins in the hypothalamus, but has a weaker effect on the synthesis and release of peripheral prostaglandins. It does not affect platelets or the coagulation mechanism. It is primarily used as an antipyretic and analgesic in small and medium-sized animals for fever, muscular pain, joint pain, and rheumatism.
Pharmacokinetics: It is rapidly absorbed after oral administration, reaching peak plasma concentrations within 30 minutes. It is primarily metabolized in the liver, with the majority conjugated with glucuronic acid or sulfate and excreted renally. In the liver, a portion of the drug is deacetylated to form p-aminophenol, which is then oxidized to N-acetyl-p-benzoquinone imine. This iminoquinone can oxidize hemoglobin in vivo, reducing its oxygen-carrying capacity, potentially leading to adverse effects such as tissue hypoxia, cyanosis, hemolysis, jaundice, and hepatic damage.
What is the Physicochemical Properties of Paracetamol Tablets?
This product is a white tablet.
Uses
What is Paracetamol Tablets used for?
Antipyretic and analgesic agent. Used for fever, muscular pain, joint pain, and rheumatism.
Dosage
How much Paracetamol Tablets should be given to an animal?
Oral administration: Single dose: 20–40 tablets for horses and cattle; 2–8 tablets for sheep; 2–4 tablets for pigs; 0.2–2 tablets for dogs.
Side Effects
What are the potential side effects of Paracetamol Tablets in different animal species?
Occasional anorexia, vomiting, hypoxia, cyanosis, hemolysis, jaundice, and hepatic injury may occur.
What are the common dosage forms of Paracetamol Tablets?
0.5g.
What are the Precautions of Paracetamol Tablets?
(1) Contraindicated in cats due to the potential for severe toxic reactions after administration.
(2) High doses may cause hepatic and renal damage. Administration of acetylcysteine or methionine within 12 hours post-dose may prevent liver injury. Use with caution in animals with hepatic or renal impairment and in young animals.
(3) No withdrawal period is required.
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