What is Aspirin Tablets?
Pharmacodynamics: Aspirin exhibits significant antipyretic and analgesic effects, along with potent anti-inflammatory and anti-rheumatic activities. It can inhibit antibody production and antigen-antibody binding reactions, reduce inflammatory exudation, and demonstrates reliable efficacy against rheumatism. At higher doses, it also inhibits the reabsorption of uric acid in the renal tubules, thereby promoting uric acid excretion.
Pharmacokinetics: In monogastric animals, aspirin is rapidly absorbed in the stomach and the anterior segment of the small intestine after oral administration. Absorption is slower in cattle and sheep; approximately 70% is absorbed in cattle, with a time to peak plasma concentration of 2–4 hours and an elimination half-life of 3.7 hours. The drug is widely distributed throughout the body, with a plasma protein binding rate of 70%–90%. It can enter milk, albeit at low concentrations, and crosses the placental barrier. It is partially hydrolyzed in the stomach, plasma, red blood cells, and tissues to salicylic acid and acetic acid. Metabolism occurs primarily in the liver, forming glycine and glucuronic acid conjugates. The parent drug and its metabolites are rapidly excreted by the kidneys; excretion is slower in acidic urine and can be accelerated by urine alkalinization. The half-life of aspirin varies significantly among species: less than 1 hour in horses, 7.5 hours in dogs, and 37.6 hours in cats.
What is the Physicochemical Properties of Aspirin Tablets?
This product is a white tablet.
Uses
What is Aspirin Tablets used for?
Antipyretic, analgesic, and anti-inflammatory agent. Used for febrile diseases, muscular pain, and joint pain.
Dosage
How much Aspirin Tablets should be given to an animal?
Oral administration: Single dose: 50–100 tablets for horses and cattle; 3.3–10 tablets for sheep and pigs; 0.67–3.3 tablets for dogs.
Side Effects
What are the potential side effects of Aspirin Tablets in different animal species?
(1) This product can inhibit prothrombin synthesis. Prolonged continuous use may induce bleeding tendencies.
(2) It may cause gastrointestinal irritation. High doses can easily lead to anorexia, nausea, vomiting, and even gastrointestinal bleeding. Long-term use may induce gastric or intestinal ulcers.
What are the common dosage forms of Aspirin Tablets?
0.3g.
What are the Precautions of Aspirin Tablets?
(1) Not for use in cattle producing milk for human consumption during the lactation period.
(2) Use with caution in animals with gastritis or gastric ulcers. Administering with calcium carbonate can reduce gastric irritation. Should not be administered on an empty stomach. Vitamin K can be used to treat bleeding tendencies if they occur.
(3) During antipyresis, animals should drink plenty of water to promote sweating and reduce body temperature; otherwise, excessive sweating may lead to fluid and electrolyte imbalances or collapse.
(4) For geriatric, debilitated, or animals with very high fever, use a reduced dose during antipyresis to avoid collapse due to profuse sweating.
(5) In case of poisoning, gastric lavage, administration of cathartics, oral sodium bicarbonate, and intravenous infusion of 5% glucose and 0.9% sodium chloride can be administered as antidotes.
(6) No withdrawal period is required.
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