What is Fenbendazole Tablets?
Pharmacodynamics: Fenbendazole is a benzimidazole anthelmintic. Its mechanism of action involves binding to tubulin in nematodes to exert its anthelmintic effect. Its antiparasitic spectrum is not as broad as that of albendazole, but its potency is slightly stronger. It is highly effective against Parascaris equorum, adult and larval Oxyuris equi, Probstmayria vivipara, Strongylus vulgaris, Strongylus edentatus, Strongylus equinus, and small strongyles in horses. It demonstrates high efficacy against adult and larval stages of Haemonchus, Ostertagia, Trichostrongylus, Bunostomum, Nematodirus, Cooperia, Oesophagostomum, and Dictyocaulus viviparus in cattle. It shows excellent anthelmintic activity against adult and larval stages of Haemonchus, Ostertagia, Trichostrongylus, Cooperia, Nematodirus, Bunostomum, Chabertia, Oesophagostomum, Trichuris, and Dictyocaulus in sheep. Additionally, it inhibits egg production by most gastrointestinal nematodes. It is effective against adult and larval stages of Hyostrongylus rubidus, Ascaris suum, and Oesophagostomum spp. in pigs. A daily dose of 50 mg/kg for 3 days is highly effective against hookworms, ascarids, and whipworms in dogs and cats. A daily dose of 50 mg/kg for 5 days is highly effective against feline lungworm (Aelurostrongylus abstrusus), and for 3 days against feline stomach worms (Ollulanus tricuspis). It is also effective against gastrointestinal and respiratory nematodes in poultry.
Pharmacokinetics: After oral administration, fenbendazole is absorbed slowly in ruminants and somewhat faster in monogastric animals. The time to peak plasma concentration is 24 hours in dogs and 2–3 days in sheep. Absorbed fenbendazole is metabolized to the sulfoxide (oxfendazole, the active metabolite) and sulfone. In cattle, sheep, and pigs, 44%–50% of fenbendazole is excreted unchanged in feces, with less than 1% excreted in urine. A single dose is ineffective in dogs and cats; a 3-day treatment course is required.
What is the Physicochemical Properties of Fenbendazole Tablets?
This product is a white or off-white tablet.
Uses
What is Fenbendazole Tablets used for?
Anthelmintic agent. Used for nematode and cestode infections in livestock and poultry.
Dosage
How much Fenbendazole Tablets should be given to an animal?
Oral administration: Single dose: 0.5–0.75 tablets per 10kg body weight for horses, cattle, sheep, and pigs; 1–5 tablets for poultry; 2.5–5 tablets for dogs and cats. Administer for 3 consecutive days.
Side Effects
What are the potential side effects of Fenbendazole Tablets in different animal species?
When used as directed, adverse reactions are generally not observed. An allergic reaction may occur secondary to the release of antigens from dead parasites, particularly at high doses. Occasional vomiting has been reported in dogs or cats after oral administration. In one reported case, a dog developed panleukopenia after administration.
What are the common dosage forms of Fenbendazole Tablets?
0.1g.
What are the Precautions of Fenbendazole Tablets?
(1) Not for use in horses intended for human consumption.
(2) May have teratogenic and embryotoxic effects; contraindicated during early pregnancy.
(3) Withdrawal period: Cattle and sheep: 21 days; Pigs: 3 days; Poultry: 28 days. Milk discard period: 7 days; Egg discard period: 7 days.
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