Antihelminthics (also known as anthelmintics) are a class of drugs used to treat infections caused by parasitic worms (helminths). These drugs target and eliminate helminths that infest animals, including livestock, pets, and poultry.
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![Praziquantel]()
PraziquantelPraziquantel is an ideal new broad-spectrum anthelmintic effective against cestodes and trematodes. Its mechanism of action has not been fully elucidated but may involve promoting the influx ofread more -
![Doramectin]()
DoramectinDoramectin is a novel broad-spectrum antiparasitic agent. Its antiparasitic spectrum and pharmacological action are similar to those of ivermectin, but it exhibits slightly greater efficacy and lowerread more -
![Albendazole]()
AlbendazoleAlbendazole is currently the most widely used anthelmintic drug with high efficiency, broad spectrum and low toxicity.Albendazole can repel adults and larvae of nematodes, tapeworms and flukesread more
Antihelminthics are categorized based on the type of helminths they target and their chemical structure. The main classes include:
Benzimidazoles
Examples: Albendazole, Fenbendazole, Mebendazole, Oxfendazole
Target: Broad-spectrum; effective against nematodes (roundworms), cestodes (tapeworms), and some trematodes (flukes).
Macrocyclic Lactones
Avermectins: Ivermectin, Doramectin, Eprinomectin
Milbemycins: Moxidectin, Milbemycin oxime
Target: Primarily nematodes (especially gastrointestinal and lungworms) and ectoparasites (e.g., mites).
Imidazothiazoles
Examples: Levamisole
Target: Nematodes (stimulates paralysis in worms).
Tetrahydropyrimidines
Examples: Pyrantel, Morantel
Target: Nematodes (neuromuscular blockers).
Organophosphates
Examples: Dichlorvos, Trichlorfon
Target: Nematodes and some ectoparasites (inhibit acetylcholinesterase).
Salicylanilides & Substituted Phenols
Examples: Closantel, Niclosamide, Oxyclozanide
Target: Trematodes (flukes) and cestodes (tapeworms).
Praziquantel & Derivatives
Examples: Praziquantel, Epsiprantel
Target: Cestodes (tapeworms) and trematodes (flukes).
Amino-Acetonitrile Derivatives (AADs)
Example: Monepantel
Target: Nematodes (particularly resistant strains).
Spiroindoles
Example: Derquantel (used in combination with abamectin)
Target: Nematodes.
Natural Compounds
Examples: Piperazine (neuromuscular blocker), Emodepside (cyclooctadepsipeptide)
Target: Nematodes.
Usage Considerations:
Spectrum of activity (broad vs. narrow)
Resistance management (due to overuse in livestock)
Safety profile (species-specific toxicity, e.g., ivermectin sensitivity in Collies)
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